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KMID : 0616120170480040289
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 4 p.289 ~ p.297
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Effect of Snail(Fruticiola sieboldiana) Extract on Reactive Oxygen Species(ROS) in Old Female Rats
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Sohn Gee-Ho
Kim Tae-Hee
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Abstract
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This study was performed to investigate the effect of 8 weeks administration of snail extract on free radical formation in old female rats (27 weeks). Rats administrated orally with snail extract at the dose of 100 mg/kg, 200 mg/kg, chondroitin sulfate 10 mg/kg and 0.9% saline (control) for 8 weeks. Hematologic profiles and hepatic enzymes were all normal. Results of analysis on snail extract were naicin, Na, protein, sugar, beta-carotene, vitamin (A, B1, B2, B6, C, E), folic acid, phosphorus, lipid, K, cholesterol, chondroitin. Hepatic lipid peroxidase content was decreased, aldehyde oxidase was decreased, glutathione peroxidase and glutathione-S transferase were not changed, but xanthine oxidase, catalase and superoxidase activities were significantly increased in snail extract fed group (p<0.001). Therefore, as the result of this study, it could be expected that the administration of snail extract for 8weeks is the potential to be use as a hepatic anti-oxidative agent.
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KEYWORD
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Snail, Fruticiola sieboldiana, Reactive oxygen species (ROS)
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